It is an anticonvulsant, non-sedative drug which is used in the treatment of epilepsy. Male patients after the use of this drug complained of impotence. Chemically it is regarded as NO3 group name Antiepileptic. Its generic name is 5, 5 diphenyl-substituted hydantoin Trade Name; Epigran, Dilantin, Dantonio (1). Phenytoin is excreted in human semen in small quantities, and this may affect the testosterone levels. Reduce the plasma concentration of free testosterone that has been detected in male epileptic patients receiving phenytoin. For those patients who are receiving phenytoin, the serum level of testosterone is reduced (2). It has been observed that phenytoin has a mutagenic effect on human sperm cells. It is observed that hyposexulity and the low fertility rate are greater in epileptic patients than in the general population. There are reports that they reduce testicular weight, spermatic count, and gives abnormal morphology of spermatozoa. They reduce spermatozoa’s motility to interfere with the normal HPG (hypophyseal gonadal) pathway (3). Its biological name is Cocoas nucifera.
The coconut oil is abstracted by mechanical means from the mature kernel of the coconut with or without heat and without chemical refining called Virgin coconut oil. Virgin coconut oil is derived from COPRA. Myristic acid and Lauric acid are related to the average serum cholesterol concentration in humans. The lauric acid level in coconut is controlled by environment and genetics (4). Lauric acid is a fatty acid derived from coconut for developing monolaurin. Monolaurin is an antimicrobial agent for killing bacteria, yeasts, and viruses. Coconut oil contains flavonox and poly phenol, that have potent antioxidant effects, particularly in male fertility (5). The corn oil is composed of Triacylglycerol 99% and Poly Unsaturated fatty acids (PUFA). Sperm cells contain a high proportion of (PUFA), and normal spermatozoa possess a high % of PUFA (6). These PUFA are formed from linoleic acid (LA), and they give fluidity to the sperm plasma membrane, which helps in the fusion events of fertilization. More recently, antioxidants (AOX) and Phytosterols (PST), commonly found in substantial amounts in special oils, such as Pecan nut (PNO) Corn (CO) and grape seed (GSO) oils (7-8). These oils are associated with a lower risk of inflammation, dyslipidemia, and low risk of oxidative stress required for the maintenance of endothelial integrity (9-10).