A Science Research paper
The article title here is Uterine Fibroid Research: A Work in Progress https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212348/. It is an article written by James H. Segars and published in 2014. The article is essential in the sense that it gives the foundation and some causes of uterine fibroids. However, the article points out that about 25% of the African American women who are from the age of 25 to the age of menopause tend to develop uterine fibroids. I accept the fact that uterine fibroids are the health disparities affecting women from all races. Understandably, uterine fibroid has a limited level of treatment. Moreover, researches accept that it is sparse in the scope of this disease. Ideally, researches are needed further to bend to the way o uterine fibroids. Assertively, tumor biology, mechanical signaling, genetics, angiogenesis, and genetics have to be together be put together for a better result. Thus, future researches should point at these fields and look for a mechanism of channeling the fields in the treatment of uterine fibrosis. The growth of uterine fibrosis is rapid, but it will rarely metalize (Segars, 2014). Treatment of uterine fibrosis is costly; thus, there is a need for investments in resources and also the allocation of various governments to research and treat uterine fibrosis. Reproductive Science is essential since researchers need dividend investment to prevent the disease. Pathophysiology of the uterine fibrosis, root causes, and the growth of fibroids are also outlined in this article, and they are scoped towards analytical comparison about the disease and other female reproductive diseases amongst people of different races. Conclusively, the article reports that the disease is found in all races across the world. Learnedly, reproductive science is the way to liberating the patients against the uterine fibroids.
Recent Scientific advances in leiomyoma (uterine fibroids) research facilitate better understanding and management, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513689/, the authors, Darlene et al., in 2015. Argue that the management of uterine leiomyomas has shown slow but steady advancement over the years—the understanding of the underlying mechanisms in the initiation and development of molecular biology of leiomyomas. Review in the article points out the standard medical therapies as strategies for treatment. However, the African-American develop uterine fibroids at a tender age and start to decrease when the rate of growth is higher, just before menopause. Leiomyoma cell secretes higher levels of disarrayed and altered collagen fibrils, fibrinogen, and other extracellular matrix components and resists apoptosis. However, the fibroids in the uterine walls vary in location and may be up to 20 cm or even higher (Taylor et al., 2015). However, conditions vary in that the tumors in other patients may be one while other patients may exhibit multiple tumors of uterine fibroids. Mechanotransduction is the response of cells to the mechanical forces like a stretch, compression, and biochemical influences in all the cells. The role of mechanotransduction in leiomyoma is to stimulate the initiation of the growth of uterine fibrosis. However, both the biochemical factors and biomechanical factors are essential fo the studies to locate the cause of the available changes that occur in the uterine smooth muscles. However, future studies should have a scope on the analysis of genetic abnormalities. There ought to be a comparative analysis on the chromosomal rearrangement that fibroids have o that treatment mechanisms may be realized. The researches should rely on the cultured cells and human tissues in the specimens from surgery.
The same ideas are proposed by Zimmerman A. in Prevalence, symptoms, and management of uterine fibroids: an international internet-based survey of 21,746 women https://bmcwomenshealth.biomedcentral.com/articles/10.1186/1472-6874-12-6. This article was published in 2012, and it is essential and influential in analyzing the possible symptoms and management of this disease. However, the research was based on a case study on the research conducted in 2009 about uterine bleeding and pain Women’s Research Study (UBP-WRS. However, the research was done in about eight countries, thus relying on the research data. There are cases of self-reported pre3valence on uterine fibrosis in all the countries that the research was conducted. 1.8% is the percentage increase of the uterine fibroid cases for the women who range from the age of 20 to 29 years (Zimmermann et al., 2012). However, one can be right when he or she says the birth cases increase the tendency of one contracting uterine fibrosis. Asserted from this research, the women who had children tested more positive on uterine fibrosis than those who did not have children. However, the paper is essential as it states that the frequent bleeding from the uterine may serve ad the symptom of uterine fibrosis. However, the research should concentrate on one field alone like, for example, the bleeding symptoms and explore this field to the later for efficiency and quality results.
Aamir T.K., Amnjeet S., and Janesh K.G wrote Uterine fibroids: current perspectives https://www.researchgate.net/publication/260132082_Uterine_fibroids_Current_perspectives in the year 2014. As seen, the leading cause of morbidity in women in uterine fibrosis. It attacks the men who are form the reproductive age. However, in some cases, even the women in menopause experience uterine fibroids. However, the fibroids affect the pelvic pressure or the menstrual cycle of women. An example of uterine fibrosis is leiomyosarcoma, which is so dangerous that is affects the women even after reaching menopause (Khan, Shehmar, & Gupta, 2014). Thus, the women who are also past the menopause age also risk contracting uterine fibroids. However, further directions on the disease should point at the factors that cause since the study concludes that alcohol and caffeine increase the risk of getting the uterine fibroids. However, there are very many people in the world consuming the two chemicals and do not have the disease; thus, the need to conduct further researches on the same to ascertain that statement. Moreover, the researchers should direct on the measures of combating uterine fibroids; these measures should be efficient and must have the scientific backing.
In the Burden of uterine fibroids: a search for primary and secondary prevention https://www.fertstert.org/article/S0015-0282(18)32157-5/fulltext, the author, Quaker E. Harmon presents the fact that the uterine fibroids are not just prevalent in have and burden-effect on experienced women in the disease and those undergoing the symptoms. However, the analysis points out that more than 80% of the patients are blacks, while about 70 % of those who exceed the whites are the age of about 50 years (Harmon, 2019. However, there is a possibility that there are women who are asymptomatic and do not show any signs and symptoms of the disease. Ideally, the treatment options of fibroids may limit the future of some women on having children. The prevalence of undiagnosed fibroids makes it a challenge for the study of the results it yields on society. However, the good news is that uterine fibroids, if screened, can be treated, and the patient becomes free from it. However, it has been noted that fibroids are prevalent in black Americans more than the white population. Thus, there is a need for further researches to point out the reasons why the uterine fibroids are leading in the back population. Moreover, the researchers should make it known to the readers about the possibility of treating the profound cases of uterine fibroids without risking the possibility of having children.
References
Harmon, Q. (2019). The burden of uterine fibroids: a search for primary and secondary prevention. Fertility And Sterility, 111(1), 50-51. https://doi.org/10.1016/j.fertnstert.2018.10.031
Khan, A., Shehmar, M., & Gupta, J. (2014). Uterine fibroids: current perspectives. International Journal Of Women’s Health, 95. https://doi.org/10.2147/ijwh.s51083
Segars, J. (2014). Uterine Fibroid Research. Reproductive Sciences, 21(9), 1065-1066. https://doi.org/10.1177/1933719114546644
Taylor, D., Holthouser, K., Segars, J., & Leppert, P. (2015). Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management. F1000research, 4, 183. https://doi.org/10.12688/f1000research.6189.1
Zimmermann, A., Bernuit, D., Gerlinger, C., Schaefers, M., & Geppert, K. (2012). Prevalence, symptoms, and management of uterine fibroids: an international internet-based survey of 21,746 women. BMC Women’s Health, 12(1). https://doi.org/10.1186/1472-6874-12-6