Antimicrobial resistance discussion critic
The writer has offered great insight into the discussion on antimicrobial resistance. It is true that tetracycline has been widely used antibiotics because of its low toxicity and a broad spectrum of activity. It has been very effective in treating multiple infections, along with controlling acne. Moreover, the writer is right in the post because the use of tetracycline has been declining due to resistance, which generally affects its effectiveness in controlling various bacterial infections to foster the standard of life of patients. Additionally, the writer has shed light on the mechanism of resistance.
Nonetheless, the writer has not exhausted all the mechanisms by which tetracycline resistance is conferred to an organism. The writer has only discussed on efflux along with ribosomal protection as the only mechanism of tetracycline resistance; however, there is enzymatic inactivation as the mechanism for tetracycline resistance. In enzymatic inactivation, the drug is decomposed inside the cell. As compared to other mechanisms, enzymatic inactivation is a less common mechanism of resistance. Also, the writer has not offered a discussion on how the efflux mechanism is regulated. Attenuation mechanisms usually regulate the efflux mechanism. Recently it was reported that at least one of the ribosome protection genes is regulated by attenuation. Besides, the writer has not offered in-depth insight on gram-positive bacteria. Gram-positive bacteria were the first element to be discovered to be capable of transmitting tetracycline resistance from cell to cell and amidst bacteria species. The writer has offered great insight into the discussion, though some further research needs to be done to provide in-depth intuition on the mechanism of tetracycline resistance.