Introduction to Bio-Chemistry
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Immunoproteasome describes the very competent protein-composed equipment obtained from the integral proteasome. Immunoproteasome is bountifully manifested in unsusceptible cells. Proteasome influences the deaming of cellular proteins, getting rid of damaged proteins (Basler, Kirk & Groettrup, 2013). Immunoproteasome also controls processes of the cells, for example, gene expression, growth, apoptosis, and proliferation. Studies also indicated that non-immune cells have immunoproteasome which aids in differentiation and proper functioning of the cells.
Cytokines are a group of peptides aiding in the signaling of cells and are produced by particular cells of the human body (Lundh, Bugliani, Dahlby, Chou, Wagner, Ghiasi, Tata, Chen, Lund, Davies, Marchetti & Poulsen). Cytokines play several roles in forming immunoproteasome. Some of these roles include; influencing how immunoproteasome is expressed. The functioning of the immunoproteasome in the cells is also regulated by cytokines. Suppression of immunoproteasome provokes apoptosis, a beta cell brought about by cytokines, and minimizes the amounts of oxidized proteins located inside the cells.
References
Basler, M., Kirk, C. J., & Groettrup, M. (2013). The Immunoproteasome in antigen processing and other immunological functions. Current opinion in immunology, 25(1), 74-80.
Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H. C., Wagner, B., Ghiasi, S. M., & Marchetti, P. (2017). The immunoproteasome is induced by cytokines and regulates apoptosis in human islets. The Journal of endocrinology, 233(3), 369.