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                                Medical Uses of Radioisotopes

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Student Name

 

Centre

 

Unit Title             Code     11030

                                Medical Uses of Radioisotopes

 

Assignment Title – Medical Uses of Radioisotopes

 

This unit is graded

Grade descriptors: 1, 2, 3, 5 & 7

No of credits:   3
Date set

 

 

Date dueDate submitted
If a resubmission

 

 

Date dueDate submitted
Access Assignment Coversheet

Subject: Physics

Level 3

Student Declaration:

I understand that copying / taking ideas from other sources (e.g. reference books, journals, internet, and tutor handouts) without acknowledging them is plagiarism. I confirm that:

  • This assignment is all my own work
  • All contributions taken from other reading and research have been referenced accurately
  • Any direct quotations taken from other reading and research have been acknowledged and attributed accurately
  • I have attached a bibliography listing all sources used in producing this assignment.
  • I have added the word count below.
  • I have read and understood the Ascentis document entitled ‘Policies and Procedures for Dealing with Malpractice’ provided by the tutor and understand the consequences of non-compliance with this document.

 

To be completed by student on submission and in confirmation of above declaration:
Student name (printed)

 

Student signature

 

Word count
To be completed by tutor:
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Tutor signature

 

Unit grade awarded:Word count confirmed as accurate:
To be completed by the ISM (Internal Standards Moderator) if work has been internally moderated:
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Date internally moderated
Answer all questions
Q1

AC1.1

Define the terms ‘radioisotope’ and ‘radiopharmaceutical’.
Q2

AC1.2

 

Describe the production processes used to prepare samples of the following radioisotopes :

 

a) Technetium-99m

b) Cobalt-60

c) Iodine-131

 

Q3

AC1.3

 

Referring to the table below:

a) Describe the radiological properties of diagnostic and therapeutic radionuclides that make them suitable for purpose.

b) Describe the biological properties of radionuclides that make them suitable for purpose.

 

Treatment AreaRadionuclideHalf-life (T1/2)
HeartThallium-201 (201Tl)

Technetium-99m (99mTc)

3 days

6 hours

ThyroidIodine-123 (123I)

Iodine-131 (131I)

Technetium-99m (99mTc)

13 hours

8 days (treatment)

6 hours

BoneCalcium-47 (47Ca)

Technetium-99m (99mTc)

4.5 days

6 hours

Liver

Lungs

Kidneys & bladder

Brain

Tumours

Blood

Xenon-133 (133Xe) (lungs)

Iodine-123 (123I) (brain)

Technetium-99m (99mTc)

5.2 days

13 hours

6 hours

TumorsCobalt-60 (60Co)5.3 years

 

 

Q4

AC2.1

State the function of a gamma camera and explain how it works. Include a labelled diagram.

 

 

 

Q5

AC2.2

 

Compare and contrast the use of the following radioisotopes in diagnostic imaging. Summarise their radiological and biological properties, identifying the imaging equipment required for their use.

 

a) Thallium-201 (201Tl)

b) Xenon-133 (133Xe)

c) Technetium-99m (99mTc)

d) A radioisotope of your choice

 

Q6

AC2.3

 

Identify the appropriate treatment (therapeutic radionuclide, brachytherapy or x-ray therapy) for the following types of tumour and justify your choice.

 

·         Multiple small tumours

·         Shallow isolated tumour

·         Tumour in close proximity to a radiosensitive organ

 

Q7

AC3.1

 

Explain the possible effects of a range of types of radiation on animal cells. Identify stochastic effects and deterministic effects. Briefly describe methods of monitoring radiation dose and outline how this information can help to alleviate deterministic effects.

 

Q8

AC3.2

 

Compare and contrast the consequences of radiation damage to somatic cells and to germ line cells.

 

Q9

AC3.3

 

Estimate the number of decays each day for the following radioisotopes:

a)             Diagnostic radioisotope with activity 52MBq.

b)             Therapeutic radioisotope with activity 3800TBq.

 

Q10

AC3.3

 

Patient X has a 175g tumour and receives 18J of energy as part of their radiotherapy treatment. Calculate the absorbed dose received by the patient.

 

Q11

AC3.3

 

Patient Y is a worker in the nuclear medical industry. They wear a dosimeter which records their exposure to ionising radiation. During their regular check-up, the dosimeter shows that they have received an absorbed dose of 15mGy from gamma rays and an absorbed dose of 7μGy from alpha particles.

 

a)      Calculate the total equivalent dose received by the patient

b)      Calculate the effective dose received on the lungs by the patient using the tissue weighting factor WT of 0.12

 

 

 

Learning OutcomesAssessment CriteriaAchieved

Y / N

The student should be able to:The student has achieved this outcome because s/he can:
1  Understand the production of radioisotopes and their properties1.1  Define the terms ‘radioisotope’ and ‘radiopharmaceutical’

 

1.2  Describe the production of radioisotopes for use in radiopharmaceuticals and imaging

 

1.3  Explain the key properties of radioisotopes that are intended for medical use
2  Understand some of the techniques used in nuclear medicine and imaging2.1  Explain the use of the gamma camera
2.2  Explain the use of radioisotopes in diagnostic imaging and give examples
2.3  Explain the advantages from the use of radiopharmaceuticals for treatment as opposed to irradiation using external sources of radiation
3  Understand the effects of radiation on living cells and methods for monitoring radiation exposure3.1  Describe the effects of different types of radiation on cells
3.2  Distinguish between the somatic and hereditary effects of radiation
3.3  Perform calculations involving absorbed dose, exposure, relative biological effect and effective dose

 

 

 

Grading the assignment

Once the learning outcomes for this assignment are achieved, the student is eligible for grading against specific grade descriptors (these are identified on the following pages)

 

There are no descriptor components for Pass.  Students achieve a Pass by meeting the requirements of all the assessment criteria of a unit

 

1              Understanding of the subjectOnly the components that are ticked apply to this assignment
MeritDistinction
The student, student’s work or performance: The student, student’s work or performance 
a      demonstrates a very good grasp of the relevant knowledge baseüa      demonstrates an excellent grasp of the relevant knowledge baseü
b      is generally informed by the major conventions and practices of the area of studyüb      is consistently informed by the major conventions and practices of the area of studyü
c      demonstrates very good understanding of the different perspectives or approaches associated with the area of study.üc      demonstrates excellent understanding of the different perspectives or approaches associated with the area of study.ü

 

 

 

2              Application of knowledgeOnly the components that are ticked apply to this assignment
Merit Distinction
The student, student’s work or performance

makes use of relevant a

The student, student’s work or performance makes use of relevant a
•       ideasü•       ideasü
•       factsü•       factsü
•       theoriesü•       theoriesü
•       perspectives•       perspectives
•       models•       models
•       conceptsü•       conceptsü
with either

b    breadth or depth that goes beyond the minimum required to Pass

and/or

with both

b        breadth and depth

 

and/or

c       very good levels ofc        excellent levels of
•       consistencyü•       consistencyü
•       precisionü•       precisionü
•       accuracyü•       accuracyü
•       insightü•       insightü
•       analysisü•       analysisü
•       synthesis•       synthesis
•       creativity•       creativity

 

 

 

3              Application  of SkillsOnly the components that are ticked apply to this assignment
Merit Distinction
The student, student’s work or performance:The student, student’s work or performance:
a      generally selects appropriatea      consistently selects appropriate
•      skills•      skills
•      techniques•      techniques
•      methodsü•      methodsü
and / orand / or
b      applies appropriate (selected or given)b      applies appropriate (selected or given)
•      skills•      skills
•      techniques•      techniques
•      methodsü•      methodsü
c       with very good levels ofc       with excellent levels of
•      confidence•      confidence
•      consistencyü•      consistencyü
•      creativity•      creativity
•      innovation•      innovation
•      precisionü•      precisionü
•      accuracyü•      accuracyü
•      efficiency•      efficiency

 

 

 

5              Communication and presentationOnly the components that are ticked apply to this assignment
Merit Distinction
The student, student’s work or performance shows very good command of:The student, student’s work or performance shows excellent command of:
§   formatü§   formatü
§   structure§   structure
§   use of imagesü§   use of imagesü
§   language (including technical or specialist language)ü§   language (including technical or specialist language)ü
§   syntax§   syntax
§   register§   register
§   spellingü§   spellingü
§   punctuationü§   punctuationü
§   referencingü§   referencingü

 

7              QualityThis grade descriptor applies to all units
MeritDistinction
The student, student’s work or performance:The student, student’s work or performance:
a      is structured in a way that is generally logical and fluentüa      is structured in a way that is consistently logical and fluentü
b   puts forward arguments or ideas which are

      generally unambiguous but which are in a

minor way limited or incomplete

üb    puts forward arguments or ideas which

are consistently unambiguous and

cogent

ü
c      taken as a whole, demonstrates a very good response to the demands of the brief/assignmentüc      taken as a whole, demonstrates an excellent response to the demands of the brief/assignmentü

 

 

 

Tutor Feedback

Credits awarded:

Yes / No

Number of credits

 

Resubmission

Yes / No

Date for resubmissionReferral

Yes / No

Comments:

 

 

 

 

 

 

 

 

 

 

Tick if applicable to this assignmentTutor commentsPerformance against descriptor

(P / M / D)

1    Understanding of the subject   
2    Application of knowledge   
3.   Application of skills   
5    Communication and presentation   
7    Quality   
Overall unit grade   

 

 

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