Use of virgin coconut oil to observe the antioxidant effects on male fertility
Following the results of Oluwatosin et al:2016, testicular toxicity induced with the application of antiretroviral therapy, which leads to drastic effects on male fertility the same as in our study produced with phenytoin. In a similar study, the virgin coconut oil was used to observe the antioxidant effects on male fertility and sperm morphology. There was a significant reduction of sperm motility p<0.01 in animals after being treated with HAART. On the other hand, in the group of virgin coconut oil HAART, the significant restoration of numbers sperm and maintain the sperm motility almost near to the normal value. Similar findings were found in our study in a group of phenytoin and virgin coconut oil. The readings were taken at an interval of 4, 5, and 6 weeks (11, 12). The ratio of polyunsaturated fatty acids had potent inhibitory action that influences on lipid peroxidation, and Virgin coconut oil is highly rich in polyunsaturated fatty acids, so similar in our study the virgin coconut oil showed their antioxidant effects in male fertility as related in this study the virgin coconut oil evidence more significant antioxidant role in comparison with copra oil and groundnut oil. At the same time, the same results were found in our study (7,13). In the same study, the virgin coconut oil and HARRT showed a significant reduction in the diameter of seminiferous tubules; moreover, there was no effect on the germinal layer. By the results of our study, the virgin coconut oil along with phenytoin had a potent role in the restoration of tubular diameter and thickness of germinal epithelium in the animal taken long term phenytoin intra-peritoneal once daily. The effects were measure with an interval of 4, 5, and 6 weeks.
Additionally, virgin coconut oil mixed with groundnut oil or olive oil was observed to be more effective in inhibiting LDL oxidation, and stimulate hepatic antioxidant enzyme activity. The antioxidant activity of virgin coconut oil was linked to high polyphenol compounds in the oil. Polyphenols were reported to be a stronger antioxidant than vitamin C and E in vitro on a molecular basis (9, 14).